计算机科学 ›› 2019, Vol. 46 ›› Issue (1): 285-290.doi: 10.11896/j.issn.1002-137X.2019.01.044
所属专题: 医学图像
刘平平1, 张文华1, 卢振泰1, 陈韬2, 李国新2
LIU Ping-ping1, ZHANG Wen-hua1, LU Zhen-tai1, CHEN Tao2, LI Guo-xin2
摘要: 胃肠道间质瘤(GastroIntestinal Stromal Tumors,GIST)是常见的胃肠道肿瘤,具有非定向分化特征,缺乏特异性,且具有恶性潜能,所以GIST的良恶性诊断是临床较为关注的问题。然而,病理活检及CT检查等临床鉴别手段在研究肿瘤异质性方面存在一定困难。文中提出一种基于CT图像提取大量量化的放射组学特征并利用SVM分类器对GIST良恶性进行分类预测的非侵入式方法。首先,应用放射组学方法对120个患有GIST的病人的CT图像肿瘤区域分别提取4个非纹理特征和43个纹理特征。然后,应用基于ReliefF的前向选择算法进行特征选择,再用最佳特征子集训练得到的SVM分类器来对GIST良恶性进行分类预测。实验中,共有14个纹理特征入选最佳特征子集,且SVM分类模型对GIST良恶性分类的AUC、准确率、敏感性、特异性在训练集中分别为0.9949,0.9277,0.9537,0.9018;在测试集中分别为0.8524,0.8313,0.8197,0.8420。该方法以放射组学的研究方法建立的模型,为GIST良恶性预测提供了一种非入侵式的检测手段,有望成为一种辅助诊断工具,以提高临床GIST良恶性诊断的准确率。
中图分类号:
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