Computer Science ›› 2019, Vol. 46 ›› Issue (11A): 89-93.

• Intelligent Computing • Previous Articles     Next Articles

Intelligent Bone Age Assessment Based on Deep Learning

CHI Kai-kai, CAI Rong-hui, DING Wei-long, HUAN Ruo-hong, MAO Ke-ji   

  1. (School of Computer Science and Technology,Zhejiang University of Technology,Hangzhou 310023,China)
  • Online:2019-11-10 Published:2019-11-20

Abstract: The bone-ages of children and adolescents indicate their growth condition.Traditional clinical method of bone-age assessment is to observe the bone maturity of multiple particular bones inside the X-ray film of the whole left hand by the doctor’s eyes.The assessment accuracy greatly depends on the doctor’s subjective judgment ability,and the evaluation is time-consuming.At present,deep convolution neural network has been used for automated bone-age assessment based on the whole bone image of left hand.In order to improve the accuracy of bone-age assessment,this paper proposed to segment 14 specific bones used for bone-age assessment from each whole hand bone image,and then train a deep convolution neural network (AlexNet) for each one of 14 specific bones to evaluate the bone maturity level.In addition,considering that bone development is a continuous process,unlike selecting some discrete growth-level of bone in the traditional method,this paper uses the classification probabilities of the two most probable levels outputted by the automated neural network to calculate the weighted score.The test results show that the proposed method has the average bone-age error of 0.456 year and has an accuracy of 94.64% when the allowed error range which 1.0 year,which is significantly better than the automated bone-age assessment method based on the whole hand image.

Key words: Accuracy rate, Bone-age assessment, Convolutional neural network, Deep learning

CLC Number: 

  • TP391
[1]HAMILTON W J.Radiographic Atlas of Skeletal Development of the Hand and Wrist[J].Journal of Anatomy,1951,85(Pt 1):103.
[2]TANNER J M,WHITEHOUSE R H.Clinical longitudinalstandards for height,weight,height velocity,weight velocity,and stages of puberty[J].Archives of Disease in Childhood,1976,51(3):170-179.
[3]邵伟东,金春华,等.中国儿童手腕部骨龄评测标准-CHN 法与参考图谱[M].北京:中国协和医科大学出版社,2018.
[4]CHING T,HIMMELSTEIN D S,BEAULIEU-JONES B K,et al.Opportunities and obstacles for deep learning in biology and medicine[J].Journal of the Royal Society Interface,2018,15(141):20170387.
[5]KALININ A A,HIGGINS G A,REAMAROON N,et al.Deep learning in pharmacogenomics:from gene regulation to patient stratification[J].Pharmacogenomics,2018,19(7):629-650.
[6]ANTHIMOPOULOS M,CHRISTODOULIDIS S,EBNER L,et al.Lung Pattern Classification for Interstitial Lung Diseases Using a Deep Convolutional Neural Network[J].IEEE Transactions on Medical Imaging,2016,35(5):1207-1216.
[7]RAKHLIN A,SHVETS A,IGLOVIKOV V,et al.Deep Convolutional Neural Networks for Breast Cancer Histology Image Analysis[C]∥International Conference Image Analysis and Re-cognition.Cham:Springer,2018:737-744.
[8]SETIO A A,CIOMPI F,LITJENS G,et al.Pulmonary Nodule Detection in CT Images:False Positive Reduction Using Multi-View Convolutional Networks[J].IEEE Transactions on Medical Imaging,2016,35(5):1160-1169.
[9]THODBERG H H,KREIBORG S,JUUL A,et al.The BoneXpert Method for Automated Determination of Skeletal Maturity[J].IEEE Trans Med Imaging,2009,28(1):52-66.
[10]IGLOVIKOV V I,RAKHLIN A,KALININ A A,et al.Paediatric bone age assessment using deep convolutional neural networks[M]∥Deep Learning in Medical Image Analysis and Multimodal Learning for Clinical Decision Support.Cham:Springer,2018:300-308.
[11]HAO P,CHEN Y,CHOKUWA S,et al.Skeletal Bone Age Assessment Based on Deep Convolutional Neural Networks[C]∥Pacific Rim Conference on Multimedia.Cham:Springer,2018:408-417.
[12]WANG S,SHEN Y,ZENG D,et al.Bone age assessment using convolutional neural networks[C]∥2018 International Conference on Artificial Intelligence and Big Data (ICAIBD).Chengdu:IEEE Press,2018:175-178.
[13]HINTON G E,SALAKHUTDINOV R R.Reducing the dimensionality of data with neural networks[J].Science,2006,313(5786):504-507.
[14]焦李成,杨淑媛,刘芳,等.神经网络七十年:回顾与展望[J].计算机学报,2016,39(8):1697-1716.
[15]LECUN Y,KAVUKCUOGLU K,FARABET C.Convolutional networks and applications in vision[C]∥2010 International Symposium on Circuits and Systems (ISCAS).Paris:IEEE Press,2010:253-256.
[16]HUBEL D H,WIESEL T N.Receptive fields,binocular interaction and functional architecture in the cat’s visual cortex[J].The Journal of physiology,1962,160(1):106-154.
[17]KRIZHEVSKY A,SUTSKEVER I,HINTON G E.Imagenetclassification with deep convolutional neural networks[C]∥Advances in Neural Information Processing Systems.South Lake Taboe,US,2012:1097-1105.
[18]白琮,黄玲,陈佳楠,等.面向大规模图像分类的深度卷积神经网络优化[J].软件学报,2018,29(4):137-146.
[19]O’SHEA K,NASH R.An introduction to convolutional neural networks[J].arXiv:1511.08458,2015.
[20]BOUREAU Y L,PONCE J,LECUN Y.A theoretical analysis of feature pooling in visual recognition[C]∥Proceedings of the 27th International Conference on Machine Learning (ICML-10).2010:111-118.
[21]GU J,WANG Z,KUEN J,et al.Recent advances in convolutionalneural networks[J].Pattern Recognition,2018,77:354-377.
[22]LECUN Y,BOTTOU L,BENGIO Y,et al.Gradient-basedlearning applied to document recognition[J].Proceedings of the IEEE,1998,86(11):2278-2324.
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