计算机科学 ›› 2015, Vol. 42 ›› Issue (7): 262-264.doi: 10.11896/j.issn.1002-137X.2015.07.056

• 人工智能 • 上一篇    下一篇

基于蛋白质进化配对的残基间距离约束挖掘方法

王彩霞,吕 强,李海鸥,罗 升   

  1. 苏州大学计算机科学与技术学院 苏州 215006,江苏省计算机信息处理技术重点实验室 苏州215006,苏州大学计算机科学与技术学院 苏州 215006,苏州大学计算机科学与技术学院 苏州 215006
  • 出版日期:2018-11-14 发布日期:2018-11-14
  • 基金资助:
    本文受国家自然科学基金(61170125)资助

Mining Residues Distance Constraints from Protein Evolution Couplings by Classification

WANG Cai-xia, LV Qiang, LI Hai-ou and LUO Sheng   

  • Online:2018-11-14 Published:2018-11-14

摘要: 蛋白质的进化配对是指在进化过程中残基对之间形成的相对稳定的相互作用。基于已被发现的进化配对,采用机器学习的分类技术,将其转换成残基对之间的距离约束,从而将一种定性的残基对之间的相互作用挖掘为定量的距离约束,这为蛋白质的结构预测提供了新的指导。

关键词: 进化配对,距离约束,支持向量机

Abstract: Protein evolution couplings refer to the relatively stable interactions between residues formed in the process of evolution.Based on the known evolution couplings,we adopted machine learning classification technique to convert evolution couplings into distance constraints,thus quantitative residues distance constraints are extracted from qualitative protein evolution couplings between residues,which can be used as a new guidance for the prediction of protein structure.

Key words: Evolution coupling,Distance constraint,SVM

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