计算机科学 ›› 2015, Vol. 42 ›› Issue (11): 251-255.doi: 10.11896/j.issn.1002-137X.2015.11.051
何云,皮德常
HE Yun and PI De-chang
摘要： 基因表达数据时常出现缺失,阻碍了对基因表达的研究。提出了一种新的相似性度量方案——精简关联度,在此基础上,又提出了基于精简关联度的缺失数据迭代填补算法(RKNNimpute)。精简关联度是对灰色关联度的一种改进,能达到与灰色关联度同样的效果,却显著降低了算法的时间复杂度。RKNNimpute算法以精简关联度作为相似度量,将填补后的基因扩充到近邻的候选基因集,通过迭代的方式填补其他缺失数据,提高了算法的填补效果和性能。选用时序、非时序、混合等不同类型的基因表达数据集进行了大量实验来评估RKNNimpute算法的性能。实验结果表明,精简关联度是一种高效的距离度量方法,所提出的RKNNimpute算法优于常规填补算法。
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