Abstract: As the complexity of DNA computational requirements increases,the corresponding DNA logic circuit models have become more intricate.To address the low applicability of current DNA switching circuits(DSC) modeling methods,the high time cost for network stabilization,and the limited number of output signals,This paper proposed the “0-1” network.This network aimed to construct molecular models of logic circuits using DSC,allowing flexible configuration of the number of output signals in multi-output logic circuits,thus expanding the modeling scope.By leveraging the programmability of DNA strands,a “transit station” molecular structure was designed to ensure smooth current flow within the circuit and reduce the stabilization time of the response network.Additionally,based on the DNA strand displacement principle,a DNA inert circuit was constructed,utilizing the mutual exclusivity of three output signals to ensure their independent expression while reducing the overall circuit size.Finally,combining the proposed method,DSC models for consistency discriminative circuits,binary classification networks,and feature discriminative networks were constructed and verified through Visual DSD simulations.The simulation results show that the proposed method not only simplifies the circuit structure but also accelerates the stabilization of the response network.These DSC-based logic circuit models demonstrate the potential of using biomolecules for signal processing.

Key words: DNA computing, DSC, Logic circuit, Inert circuit, Feature discrimination networks