Computer Science ›› 2015, Vol. 42 ›› Issue (7): 262-264.doi: 10.11896/j.issn.1002-137X.2015.07.056

Previous Articles     Next Articles

Mining Residues Distance Constraints from Protein Evolution Couplings by Classification

WANG Cai-xia, LV Qiang, LI Hai-ou and LUO Sheng   

  • Online:2018-11-14 Published:2018-11-14

Abstract: Protein evolution couplings refer to the relatively stable interactions between residues formed in the process of evolution.Based on the known evolution couplings,we adopted machine learning classification technique to convert evolution couplings into distance constraints,thus quantitative residues distance constraints are extracted from qualitative protein evolution couplings between residues,which can be used as a new guidance for the prediction of protein structure.

Key words: Evolution coupling,Distance constraint,SVM

[1] Marks D S,Colwell L J,Sheridan R,et al.Protein 3D structure computed from evolutionary sequence variation[J].PloS one,2011,6(12):e28766
[2] Hopf T A,Colwell L J,Sheridan R,et al.Three-dimensionalstructures of membrane proteins from genomic sequencing[J].Cell,2012,149(7):1607-1621
[3] Wang Zhi-yong,Xu Jin-bo.Predicting protein contact map using evolutionary and physical constraints by integer programming[J].Bioinformatics,2013,29(13):i266-i273
[4] Ma Jian-zhu,Wang Sheng,Xu Jin-bo.Joint Multi-family Evolutionary Coupling Analysis for Protein Contact Prediction[J].arXiv preprint arXiv:1312.2988,3
[5] Wu Si-tao,Zhang Yang.MUSTER:improving protein sequence profile-profile alignments by using multiple sources of structure information[J].Proteins:Structure,Function,and Bioinformatics,2008,72(2):547-556
[6] Lazaridis T,Karplus M.Effective energy functions for proteinstructure prediction[J].Current opinion in structural biology,2000,10(2):139-145
[7] Jones D T,Buchan D W A,Cozzetto D,et al.PSICOV:precise structural contact prediction using sparse inverse covariance estimation on large multiple sequence alignments[J].Bioinforma-tics,2012,28(2):184-190
[8] Kryshtafovych A,Monastyrskyy B,Fidelis K.CASP Prediction Center infrastructure and evaluation measures in CASP10 and CASP ROLL[J].Proteins:Structure,Function,and Bioinformatics,2014,82(S2):7-13
[9] Ezkurdia I,Grana O,Izarzugaza J M G,et al.Assessment of domain boundary predictions and the prediction of intramolecular contacts in CASP8[J].Proteins:Structure,Function,and Bioinformatics,2009,77(S9):196-209
[10] 郭海娟,吕强,吴宏杰,等.一个识别蛋白质折叠模式的 SVM 分类器[J].生物信息学,2010(4):287-290 Guo Hai-juan,Lv Qiang,Wu Hong-jie,et al.A svm classifier for protein fold recognition[J].China Journal of Bioinformatics,2010(4):287-290
[11] Altschul S F,Koonin E V.Iterated profile searches with PSI-BLAST—a tool for discovery in protein databases[J].Trends in biochemical sciences,1998,23(11):444-447
[12] Cheng Jian-lin,Baldi P.Improved residue contact predictionusing support vector machines and a large feature set[J].BMC bioinformatics,2007,8(113):1-9

No related articles found!
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!