计算机科学 ›› 2019, Vol. 46 ›› Issue (5): 279-285.doi: 10.11896/j.issn.1002-137X.2019.05.043
所属专题: 医学图像
胡海根1, 周莉莉1, 周乾伟1, 陈胜勇1,2, 张俊康1
HU Hai-gen1, ZHOU Li-li1, ZHOU Qian-wei1, CHEN Sheng-yong1,2, ZHANG Jun-kang1
摘要: 检测与跟踪相衬显微图像序列下的癌细胞对于分析癌细胞的生命周期以及开发抗癌新药具有非常重要的意义。传统的目标跟踪方法大多应用于刚性目标跟踪或单目标跟踪,而癌细胞是非刚性且不断裂变的多目标,这就大大增加了跟踪的难度。文中以相衬显微图像序列中的膀胱癌细胞为研究对象,提出一种基于卷积神经网络(Convolutional Neural Network,CNN)的癌细胞多目标跟踪方法。该算法采用基于检测的多目标跟踪方法,首先利用深度学习检测框架Faster R-CNN卷积神经网络实现癌细胞的检测,初步获得待跟踪的癌细胞;再利用扫描圆算法(Circle Scanning Algorithm,CSA)实现黏连细胞的检测优化,进一步提高黏连区域的细胞检测精度;最后提取综合特征描述子,对卷积特征、尺寸特征和位置特征进行加权求和,实现跟踪目标的综合描述,从而实现不同帧癌细胞间的高效关联匹配,最终实现癌细胞的多目标跟踪。一系列实验结果表明,相较于传统方法,所提方法不仅在癌细胞的检测和跟踪上性能有较大的提升,而且可以有效处理目标的遮挡问题。
中图分类号:
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