Abstract: This paper proposed a new automated method to initialize level set function and a region-based active contour model based on MultiLayer level set formulation．Because of jointing segmentation and bias correction of images,the proposed model can overcome intensity inhomogeneity．Finally,considering the distance information of cerebral cortex,a thickness constraint item was added to segmentation framework．Experimental results show that our framework can segment images more precisely and much faster than the well-known LBF model．

Key words: Image segmentation framework, LBF model,MultiLayer level set method,Variational method