Abstract: Along with the explosion of high-throughput genomic information produced from such as DNA microarrays,modeling the mechanism of gene regulations and constructing gene regulatory network become an urgent task. We proposed a novel method, GN-Simulator, to simulate gene regulatory networks based on complex network theory. The real gene networks were modeled explicitly in matrixes based on the scale-free topology. According to the robust biological mechanism,we constructed artificial gene regulatory networks related topology to the dynamic stability. We considered the features of real gene network structures into the artificial system The computing experiments illustrate that GN-Simulator can simulate largcscale gene networks efficiently with high confidence level. Moreover, GN-Simulator generates various synthetic networks for testifying different algorithms performance and provides reasonable estimation on them.

Key words: Complex network, Scale-free topology, Dynamic stability, Simulation, Uene regulatory network