Abstract: In order to improve the registration speed of breast dynamic contrast enhancement magnetic resonance images (DCE MRI) which are obtained at different time points, this paper presented a registration model for breast DCE MRI using fast demon non-rigid registration algorithm with intensity correction. Original demon is based on intensity change to get deformation parameters and unsuitable for breast DCE MRI. Intensity correction between pre and post contrast images based on polynomial was suggested to overcome the problem according to the signal enhancement of the breast model. The experiment results show that the presented approach performs better than only demon algorithm and is remarkably faster than free form deformation non-rigid registration algorithm with nearly same precision.

Key words: Breast DCE MRI, Image registration, Demon algorithm, Intensity correction