Abstract: The purpose of medical image registration is to match corresponding points in spatial and anatomic location from two or more different images. A novel algorithm of medical image registration based on moving least squares was proposed. This algorithm segmented interested regions of images,and then used semi-automatic method to extract the landmark points, deformed the image using moving least sctuares, thereby achieving medical image registration. The experimental results demonstrate that the proposed algorithm is an accuracy and effective method of medical image registration.

Key words: Image segmentation, Image registration, Moving least squares(MLS)，Semi automatic points selection, Snake model