Abstract: The infectious SIRS model with artificial immunization was proposed based on SIRS model and scale-free nature on complex networks．The dynamic behavior of the model was studied through a mean-field theory．We studied the spreading of disease in the special scale-free networks through two different artificial immunization strategies,and simulated different impact of each strategy on disease spreading．The result shows that artificial immunization can effectively reduce infection rates and improve the system spreading threshold,so as to effectively control the disease spreading on complex networks.

Key words: Scale-free network,Artificial immunization,SIRS model,Immunization strategies