Computer Science ›› 2022, Vol. 49 ›› Issue (11A): 210800232-9.doi: 10.11896/jsjkx.210800232

• Image Processing & Multimedia Technology • Previous Articles     Next Articles

Review on Classification of Breast Cancer Histopathological Images Based on Convolutional Neural Network

ZHANG Xi-ke, MA Zhi-qing, ZHAO Wen-hua, CUI Dong-mei   

  1. College of Intelligence and Information Engineering,Shandong University of Traditional Chinese Medicine,Jinan 250355,China
  • Online:2022-11-10 Published:2022-11-21
  • About author:ZHANG Xi-ke,born in 1997,postgra-duate.His main research interests include medical image processing and analysis.
    MA Zhi-qing,born in 1964,professor,master supervisor.His main research interests include medical image proces-sing and analysis.
  • Supported by:
    Project of Postgraduate Education Quality Improvement Plan in Shandong Province(SDYJG19143),Key Project of Education and Teaching Research in Shandong University of Traditional Chinese Medicine in 2019(ZYZ2019009) and Special Project of Studying and Explaining the Spirit of The Fourth Plenary Session of the 19th CPC Central Committee in Shandong University of Traditional Chinese Medicine(SZQH202009).

Abstract: Histopathological examination of breast cancer is the “gold standard” for the diagnosis of breast cancer.The classification of breast cancer histopathological images based on convolutional neural network has become one of the research hotspots in the field of medical image processing and analysis.Automatic and accurate classification of breast cancer histopathological images has important clinical application value.Firstly,two public datasets widely used in the classification of breast cancer histopathological images and their evaluation criteria are introduced.Then,the research progress of convolutional neural network on two datasets is mainly elaborated.In the process of describing the research progress,the reasons for the low accuracy of some models are analyzed,and some suggestions are given to improve the performance of the models.Finally,existing problems and future prospects of breast cancer histopathological image classification are discussed.

Key words: Breast cancer, Histopathological image, Image classification, Convolutional neural networks

CLC Number: 

  • TP391
[1]World Health Organization.Latest global cancer data:Cancerburden rises to 19.3 million new cases and 10.0 million cancer deaths in 2020[J/OL].International Agency for Research on Cancer.https://www.iarc.who.int/wp-content/uploads/2020/12/pr292_E.pdf.Accessed 11th August 2021.
[2]MCCANN M T,OZOLEK J A,CASTRO C A,et al.Automated histology analysis:Opportunities for signal processing[J].IEEE Signal Processing Magazine,2014,32(1):78-87.
[3]SPANHOL F A,OLIVEIRA L S,PETITJEAN C,et al.A data-set for breast cancer histopathological image classification[J].IEEE Transactions on Biomedical Engineering,2015,63(7):1455-1462.
[4]ARESTA G,ARAÚJO T,KWOK S,et al.Bach:Grand chal-lenge on breast cancer histology images[J].Medical Image Analysis,2019,56:122-139.
[5]ARAÚJO T,ARESTA G,CASTRO E,et al.Classification of breast cancer histology images using convolutional neural networks[J].PloS One,2017,12(6):e0177544.
[6]ELMORE J G,LONGTON G M,CARNEY P A,et al.Diagnostic concordance among pathologists interpreting breast biopsy specimens[J].Jama,2015,313(11):1122-1132.
[7]LITJENS G,KOOI T,BEJNORDI B E,et al.A survey on deep learning in medical image analysis[J].Medical Image Analysis,2017,42:60-88.
[8]LECUN Y,BOTTOU L,BENGIOY,et al.Gradient-based lear-ning applied to document recognition[J].Proceedings of the IEEE,1998,86(11):2278-2324.
[9]KRIZHEVSKY A,SUTSKEVER I,HINTON G E.Imagenetclassification with deep convolutional neural networks[J].Advances in Neural Information Processing Systems,2012,25:1097-1105.
[10]SIMONYAN K,ZISSERMANA.Very deep convolutional net-works for large-scale image recognition[J].arXiv:1409.1556,2014.
[11]SZEGEDY C,LIU W,JIA Y,et al.Going deeper with convolutions[C]//Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition.2015:1-9.
[12]IOFFE S,SZEGEDY C.Batch normalization:Accelerating deep network training by reducing internal covariate shift[C]//International Conference on Machine Learning.PMLR,2015:448-456.
[13]SZEGEDY C,VANHOUCKE V,IOFFE S,et al.Rethinking the inception architecture for computer vision[C]//Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition.2016:2818-2826.
[14]SZEGEDY C,IOFFE S,VANHOUCKE V,et al.Inception-v4,inception-resnet and the impact of residual connections on lear-ning[C]//Proceedings of the AAAI Conference on Artificial Intelligence.2017.
[15]HE K,ZHANG X,REN S,et al.Deep residual learning forimage recognition[C]//Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition.2016:770-778.
[16]HE K,ZHANG X,REN S,et al.Identity mappings in deep residual networks[C]//European Conference on Computer Vision.Cham:Springer,2016:630-645.
[17]HUANG G,LIU Z,VAN DER MAATEN L,et al.Densely connected convolutional networks[C]//Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition.2017:4700-4708.
[18]SPANHOL F A,OLIVEIRA L S,PETITJEAN C,et al.Breast cancer histopathological image classification using convolutional neural networks[C]//2016 International Joint Conference on Neural Networks(IJCNN).IEEE,2016:2560-2567.
[19]GU Y,YANG J.Densely-connected multi-magnification hashing for histopathological image retrieval[J].IEEE Journal of Biomedical and Health Informatics,2018,23(4):1683-1691.
[20]SONG Y,ZOU J J,CHANG H,et al.Adapting fisher vectorsfor histopathology image classification[C]//2017 IEEE 14th International Symposium on Biomedical Imaging(ISBI 2017).IEEE,2017:600-603.
[21]SONG Y,CHANG H,HUANG H,et al.Supervised intra-embedding of fisher vectors for histopathology image classification[C]//International Conference on Medical Image Computing and Computer-Assisted Intervention.Cham:Springer,2017:99-106.
[22]HOU Y.Breast cancer pathological image classification based on deep learning[J].Journal of X-ray Science and Technology,2020,28(4):727-738.
[23]WEI B,HAN Z,HE X,et al.Deep learning model based breast cancer histopathological image classification[C]//2017 IEEE 2nd International Conference on Cloud Computing and Big Data Analysis(ICCCBDA).IEEE,2017:348-353.
[24]HAN Z,WEI B,ZHENG Y,et al.Breast cancer multi-classification from histopathological images with structured deep learning model[J].Scientific Reports,2017,7(1):1-10.
[25]NARIN A.Performance Comparison of Balanced and Unba-lanced Cancer Datasets using Pre-Trained Convolutional Neural Network[J].arXiv:2012.05585,2020.
[26]WANG P,SONG Q,LI Y,et al.Cross-task extreme learning machine for breast cancer image classification with deep convolutional features[J].Biomedical Signal Processing and Control,2020,57:101789.
[27]GOUR M,JAIN S,SUNIL KUMART.Residual learning based CNN for breast cancer histopathological image classification[J].International Journal of Imaging Systems and Technology,2020,30(3):621-635.
[28]GUPTA V,BHAVSAR A.Sequential modeling of deep features for breast cancer histopathological image classification[C]//Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition Workshops.2018:2254-2261.
[29]VO D M,NGUYEN N Q,LEE S W.Classification of breastcancer histology images using incremental boosting convolution networks[J].Information Sciences,2019,482:123-138.
[30]MEHRA R.Breast cancer histology images classification:Trai-ning from scratch or transfer learning?[J].ICT Express,2018,4(4):247-254.
[31]DENIZ E,ŞENGÜR A,KADIROĞLU Z,et al.Transfer lear-ning based histopathologic image classification for breast cancer detection[J].Health Information Science and Systems,2018,6(1):1-7.
[32]KHAN S U,ISLAM N,JAN Z,et al.A novel deep learning based framework for the detection and classification of breast cancer using transfer learning[J].Pattern Recognition Letters,2019,125:1-6.
[33]TOĞAÇAR M,ÖZKURT K B,ERGEN B,et al.BreastNet:A novel convolutional neural network model through histopathological images for the diagnosis of breast cancer[J].Physica A:Statistical Mechanics and its Applications,2020,545:123592.
[34]BAYRAMOGLU N,KANNALA J,HEIKKILÄ J.Deep lear-ning for magnification independent breast cancer histopathology image classification[C]//2016 23rd International Conference on Pattern Recognition(ICPR).IEEE,2016:2440-2445.
[35]SPANHOL F A,OLIVEIRA L S,CAVALIN P R,et al.Deep features for breast cancer histopathological image classification[C]//2017 IEEE International Conference on Systems,Man,and Cybernetics(SMC).IEEE,2017:1868-1873.
[36]SUDHARSHAN P J,PETITJEAN C,SPANHOL F,et al.Multiple instance learning for histopathological breast cancer image classification[J].Expert Systems with Applications,2019,117:103-111.
[37]KOHL M,WALZ C,LUDWIG F,et al.Assessment of breast cancer histology using densely connected convolutional networks[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:903-913.
[38]DENG J,DONG W,SOCHER R,et al.Imagenet:A large-scale hierarchical image database[C]//2009 IEEE Conference on Computer Vision and Pattern Recognition.IEEE,2009:248-255.
[39]ROY K,BANIK D,BHATTACHARJEE D,et al.Patch-based system for Classification of Breast Histology images using deep learning[J].Computerized Medical Imaging and Graphics,2019,71:90-103.
[40]AWAN R,KOOHBANANI N A,SHABAN M,et al.Context-aware learning using transferable features for classification of breast cancer histology images[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:788-795.
[41]WEISS N,KOST H,HOMEYER A.Towards interactive breast tumor classification using transfer learning[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:727-736.
[42]CHOLLET F.Xception:Deep learning with depthwise separable convolutions[C]//Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition.2017:1251-1258.
[43]IESMANTAS T,ALZBUTAS R.Convolutional capsule net-work for classification of breast cancer histology images[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:853-860.
[44]FERREIRA C A,MELO T,SOUSAP,et al.Classification ofbreast cancer histology images through transfer learning using a pre-trained inception resnet v2[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:763-770.
[45]GUO Y,DONG H,SONG F,et al.Breast cancer histology image classification based on deep neural networks[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:827-836.
[46]WANG Z,DONG N,DAI W,et al.Classification of breast can-cer histopathological images using convolutional neural networks with hierarchical loss and global pooling[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:745-753.
[47]KONÉ I,BOULMANE L.Hierarchical resnext models forbreast cancer histology image classification[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:796-803.
[48]XIE S,GIRSHICK R,DOLLÁR P,et al.Aggregated residual transformations for deep neural networks[C]//Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition.2017:1492-1500.
[49]WANG Y,SUN L,MA K,et al.Breast cancer microscope image classification based on CNN with image deformation[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:845-852.
[50]MARAMI B,PRASTAWA M,CHAN M,et al.Ensemble network for region identification in breast histopathology slides[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:861-868.
[51]KWOK S.Multiclass classification of breast cancer in whole-slide images[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:931-940.
[52]VANG Y S,CHEN Z,XIE X.Deep learning framework formulti-class breast cancer histology image classification[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:914-922.
[53]GOLATKAR A,ANAND D,SETHI A.Classification of breast cancer histology using deep learning[C]//International Confe-rence Image Analysis and Recognition.Cham:Springer,2018:837-844.
[54]LI Y,XIE X,SHEN L,et al.Reverse active learning based atrousDenseNet for pathological image classification[J].BMC Bioinformatics,2019,20(1):1-15.
[55]RAKHLIN A,SHVETS A,IGLOVIKOV V,et al.Deep convolutional neural networks for breast cancer histology image ana-lysis[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:737-744.
[56]PIMKIN A,MAKARCHUK G,KONDRATENKO V,et al.Ensembling neural networks for digital pathology images classification and segmentation[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:877-886.
[57]MAHBOD A,ELLINGER I,ECKER R,et al.Breast cancer histological image classification using fine-tuned deep network fusion[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:754-762.
[58]CAO H,BERNARD S,HEUTTE L,et al.Improve the perfor-mance of transfer learning without fine-tuning using dissimilarity-based multi-view learning for breast cancer histology images[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:779-787.
[59]ZOPH B,VASUDEVAN V,SHLENS J,et al.Learning transferable architectures for scalable image recognition[C]//Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition.2018:8697-8710.
[60]BRANCATI N,FRUCCI M,RICCIO D.Multi-classification of breast cancer histology images by using a fine-tuning strategy[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:771-778.
[61]CHENNAMSETTY S S,SAFWAN M,ALEX V.Classification of breast cancer histology image using ensemble of pre-trained neural networks[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:804-811.
[62]VESAL S,RAVIKUMAR N,DAVARI A A,et al.Classification of breast cancer histology images using transfer learning[C]//International Conference Image Analysis and Recognition.Cham:Springer,2018:812-819.
[63]YAN R,REN F,WANG Z,et al.Breast cancer histopathological image classification using a hybrid deep neural network[J].Methods,2020,173:52-60.
[64]VETA M,PLUIM J P W,VAN DIEST P J,et al.Breast cancer histopathology image analysis:A review[J].IEEE Transactions on Biomedical Engineering,2014,61(5):1400-1411.
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