Abstract: Cancer is one of the deadliest diseases in the world.Using machine learning to process microarray data plays an important role in assisting the early diagnosis of cancer,but the numbers of genetic features are much more than samples,leading to an imbalance in the sample,and the efficiency and accuracy of classification are affected,so it is important to select the feature of gene array data.Most of the existing feature selection algorithms are single condition feature selection,which seldom consider feature extraction.Most of them use the long-existing neural network and have low classification accuracy.So,a two-stage deep feature selection(TSDFS) algorithm is proposed.The first stage aggregates three feature selection algorithms for comprehensive feature selection,and feature subsets are obtained.In the second stage,unsupervised neural network is used to obtain the best representation of feature subset and improve the final classification accuracy.This paper analyzes the effectiveness of TSDFS by comparing the classification effect before and after feature selection and different feature selection algorithms.Experimental results show that TSDFS algorithm can reduce the number of features while maintaining or improving the accuracy of classification.

Key words: Deep learning, Feature selection, Microarray data, Random forest, Variational auto-encoder